Hepatic metabolism refers to the processing and breakdown of substances by the liver. The liver plays a crucial role in metabolizing drugs, toxins, and nutrients absorbed from the intestines, as well as synthesizing proteins and other important molecules. Hepatic metabolism involves a series of complex biochemical reactions that are carried out by enzymes in the liver cells. This research area focuses on understanding the mechanisms of hepatic metabolism, how it can be affected by various factors such as disease or genetic variation, and how it can impact the efficacy and safety of drugs and other substances in the body. Studies in this area often involve in vitro and in vivo experiments, as well as computational modeling to predict drug metabolism and drug-drug interactions.